Numerous studies have attempted to understand the processes that control cancer resistance and recurrence. Cell death caused by hypoxia and metabolic stress has been extensively studied in connection with invasion. However, it remains unclear how dying or dead cells from irradiation or heat therapy promote tumor regeneration and invasion. In this article, a novel mathematical model is introduced for the first time to examine the effects of inosine on tumor recurrence and invasion. We used a finite difference based numerical approach to simulate the model. Our findings align closely with the experimental and numerical results from existing literature. We observed that cancer cells proliferate at their usual rate, but once inosine is generated from the dead cells, the intensity of cancer cell proliferation increases significantly.