Mathematical Oncology: At the Crossroads of Computational Fluids, Mechanics, and Biology
Celebrating John Lowengrub’s Contributions to Mathematical Oncology
Description
Mathematical oncology is an interdisciplinary field that leverages mathematical, computational, and theoretical approaches to address complex problems in cancer biology and treatment. In the last twenty years, mathematical oncology has played ag rowing role in driving basic and clinical cancer research, with widespread contributions from multiscale modeling. However, most cancer modeling still lacks a detailed representation of cell and tissue mechanics, and simulations generally do not integrate computational fluids beyond simple diffusion. Thus, there is considerable opportunity for mathematical oncology to benefit from deeper cross-collaboration with specialists in computational fluids and mechanics. This workshop aims to bring together researchers and students from diverse fields such as mathematics, physics, computational science, and biology to explore the intersection of computational fluid dynamics, mechanics, and biological processes in the context of cancer. Participants will exchange the latest developments in mathematical modeling, simulation techniques, and their applications to understanding tumor growth, metastasis, and treatment strategies. Workshop participants will identify opportunities to build off this exchange to better integrate computational fluids and mechanics into mathematical oncology.
This workshop will also serve as a special occasion to celebrate the 60th birthday of Professor John Lowengrub of the University of California at Irvine (UCI), an international leader and mentor in the field of mathematical oncology. His significant contributions include but are not limited to developing multiscale-multiphasic-multispecies and nonlinear fluid and solid mechanics modeling frameworks to understand the complex tumor systems, and methods in free interface and boundary problems (e.g., boundary integral methods and phase field methods), to simulate solid and vascular tumor growth, and methods in analyzing the nonlinear models. He has served as the Founding Director of Mathematical, Computational and Systems Biology Graduate Program at the University of California, Irvine and he has trained over 130 students and postdoctoral researchers, and now he serves as the Associate Dean of Research in the School of Physical Sciences at UCI.
Schedule
09:00 to 09:50 |
Thomas Hillen, University of Alberta |
09:50 to 10:30 |
Coffee Break
|
10:30 to 11:00 |
How does the tumor micro environment regulate genome organization of cancer cells?
Vivek Shenoy |
11:00 to 11:30 |
Mariam Waterman (University of California - Irvine) |
11:30 to 12:00 |
Natalia Komarova, University of California, San Diego |
12:00 to 12:30 |
Dominik Wodarz, University of California, San Diego |
12:30 to 14:00 |
Lunch
|
14:00 to 14:30 |
Thomas Hou, California Institute of Technology |
14:30 to 15:00 |
Axel Voigt, TU Dresden |
15:00 to 15:30 |
Coffee Break
|
15:30 to 16:00 |
Frederic Wan (University of Washington) |
16:00 to 16:30 |
Sid Goyal, University of Toronto |
16:30 to 17:00 |
Panel Discussion: How do these things come together?
|
17:00 to 18:00 |
Reception
|
09:00 to 09:50 |
Tipping points in cancer
John Lowengrub (University of California - Irvine) |
09:50 to 10:30 |
Coffee Break
|
10:30 to 11:00 |
Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment
Suzan Farhang-Sardroodi, University of Toronto |
11:00 to 11:30 |
Stress and growth in tumour spheroids
Davide Ambrosi (Politecno di Torino) |
11:30 to 12:00 |
Imaging-based digital twins to enable personalized clinical trials
Thomas Yankeelov (University of Texas at Austin) |
12:00 to 12:30 |
To modulate or to skip: De-escalating PARP inhibitor maintenance therapy in ovarian cancer using adaptive therapy
Sandy Anderson, Moffitt Cancer Center |
12:30 to 14:00 |
Lunch
|
14:00 to 14:30 |
How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective
Martine Ben Amar, Ecole Normale Supérieure and UPMC |
14:30 to 15:00 |
Balancing interpretability and predictive accuracy in mathematical models of T cell activation
Jun Allard, University of California - Irvine |
15:00 to 15:30 |
Coffee Break
|
15:30 to 16:00 |
Prostate: Small Organ, Big Problems—informing clinical decisions with computational models
Hector Gomez, Purdue University |
16:00 to 16:30 |
Practical Parameter Identifiability and Handling of Censored Data with Bayesian Inference in Models of Tumour Growth
Kathleen Wilkie, Toronto Metropolitan University |
16:30 to 17:00 |
Applications of extreme statistics to cellular decision making and signaling.
Alan Lindsay, University of Notre Dame |
17:00 to 17:15 |
Closing Remarks
Paul Macklin, Indiana University, Shuwang Li, Illinois Institute of Technology, Min Wu, Worcester Polytechnic Institute, Ying Chen, Purdue University |